平分型糖链的结构与功能

关锋; 丰晶晶; 卫玮; 李想; 谭增琦

doi:10.16152/j.cnki.xdxbzr.2024-05-006

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平分型糖链的结构与功能

西北大学生物学科办学100周年专刊 | 更新时间：2024-09-30

- 平分型糖链的结构与功能
- The structure and function of bisecting GlcNAc
- 西北大学学报（自然科学版） 2024年54卷第5期页码：840-846
- 作者机构：
  
  1.西北大学　生命科学学院，陕西　西安　710069
  2.西北大学　医学院，陕西　西安　710069
- 作者简介：
  
  关锋，男，博士，教授，博士生导师，从事肿瘤糖生物学研究，guanfeng@nwu.edu.cn。
- 基金信息：
  
  国家自然科学基金(82172828;32071274)
- DOI：10.16152/j.cnki.xdxbzr.2024-05-006
  中图分类号： Q53
- 纸质出版日期：2024-10-25，
  
  收稿日期：2024-08-06，
- 稿件说明：
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关锋, 丰晶晶, 卫玮, 等. 平分型糖链的结构与功能[J]. 西北大学学报（自然科学版）, 2024,54(5):840-846.

GUAN Feng, FENG Jingjing, WEI Wei, et al. The structure and function of bisecting GlcNAc[J]. Journal of Northwest University (Natural Science Edition), 2024,54(5):840-846.
关锋, 丰晶晶, 卫玮, 等. 平分型糖链的结构与功能[J]. 西北大学学报（自然科学版）, 2024,54(5):840-846. DOI： 10.16152/j.cnki.xdxbzr.2024-05-006.

GUAN Feng, FENG Jingjing, WEI Wei, et al. The structure and function of bisecting GlcNAc[J]. Journal of Northwest University (Natural Science Edition), 2024,54(5):840-846. DOI： 10.16152/j.cnki.xdxbzr.2024-05-006.

摘要

平分型N-乙酰氨基葡萄糖GlcNAc（Bisecting N-acetylglucosamine，bisecting GlcNAc）结构是指GlcNAc以β1，4-连接的方式连接到五糖核心的甘露糖（Man）上，是一种特殊的N糖基化修饰。平分型GlcNAc修饰参与多种生物过程，如细胞黏附、受精和胎儿发育、神经发生、免疫反应和肿瘤发展等。主要介绍平分型GlcNAc结构的形成过程，概述平分型GlcNAc修饰在神经系统、免疫反应、肿瘤发展和转移的生物学功能，并总结了解析平分型GlcNAc结构的技术进展，为相应生物学研究及药物开发提供科学参考。

Abstract

The bisecting N-acetylglucosamine (GlcNAc) structure

characterized by β1

4-linked GlcNAc attached to the core β-mannose residue

represents a distinctive form of N-glycosylation modification. Bisecting GlcNAc modification is implicated in numerous biological processes such as cell adhesion

fertilization and embryonic development

neurogenesis

immune responses

and tumorigenesis. This review elucidates the formation mechanisms of bisecting GlcNAc structure and highlights its diverse biological functions in the nervous system

immune response

tumor metastasis and development. Furthermore

it provides an overview of the technological advances in analyzing bisecting GlcNAc structure

providing scientific references for corresponding biological research and drug development.

关键词

平分型N-乙酰氨基葡萄糖MGAT3N聚糖质谱

Keywords

bisecting GlcNAcMGAT3N-glycanmass

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